Ningning Mi,Junjun Huang,Chongfei Huang,Yanyan Lin,Qiangsheng He,Haiping Wang,Man Yang,Yawen Lu,Atteh Lawrence Lawer,Ping Yue,Bing Bai,Jinduo Zhang,Chao Zhang,Teng Cai,Wenkang Fu,Long Gao,Xun Li,Jinqiu Yuan,Wenbo Meng

 

Abstract

Elevated serum uric acid (SUA) levelshave been previously reported to play arole in multiple types of cancers. However, epidemiological studies evaluatingSUA levels and colorectal cancer risk remain sparse. This cohort study included444 462 participants between the ages of 40 and 69 years from the UK Biobank,followed up from 2006 to 2010. Multivariable adjusted Cox regression models wereused to estimate hazard ratios (HRs). During a mean follow-up of 6.6 years, 2033and 855 cases of colon and rectal cancers, respectively, were diagnosed. Themultivariable-adjusted HRs for risks of colon cancer in the lowest uric acid catego-ries (≤3.5 mg/dL) compared with the reference groups were 1.31 (95% confidenceinterval [CI]=0.75-2.29) in males and 1.26 (95% CI=1.03-1.55) in females. TheHRs in the highest uric acid groups (>8.4 mg/dL) were 1.16 (95% CI=0.83-1.63) inmales and 2.00 (95% CI=1.02-3.92) in females. The corresponding HRs of rectalcancer in the lowest uric acid groups compared with the reference group were 2.21(95% CI=1.15-4.23) in males and 0.98 (95% CI=0.66-1.45) in females. The HRs inthe highest uric acid groups were 1.35 (95% CI=0.82-2.23) in males and 3.81(95% CI=1.38-10.56) in females. In conclusion, SUA showed a U-shaped association withcolon cancer risk in both male and female populations. The same pattern was observed inmale patients with rectal cancer. However, SUA levels were positively associated withoccurrence of rectal cancer in female subjects.

 

URL:https://onlinelibrary.wiley.com/doi/10.1002/ijc.33807